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Studies in Natural Products Chemistry, Volume 59, the latest in the
series, covers the synthesis, or testing and recording, of the
medicinal properties of natural products, providing cutting-edge
accounts of fascinating developments in the isolation, structure
elucidation, synthesis, biosynthesis and pharmacology of a diverse
array of bioactive natural products. Natural products in the plant
and animal kingdom offer a huge diversity of chemical structures
that are the result of biosynthetic processes that have been
modulated over the millennia through genetic effects. With the
rapid developments in spectroscopic techniques and accompanying
advances in high-throughput screening techniques, this book is a
welcomed resource.
Studies in Natural Products Chemistry, Volume 58, covers the
synthesis, testing and recording of the medicinal properties of
natural products, providing cutting edge accounts of fascinating
developments in the isolation, structure elucidation, synthesis,
biosynthesis and pharmacology of a diverse array of bioactive
natural products. With the rapid developments in spectroscopic
techniques and accompanying advances in high-throughput screening
techniques, it has become possible to rapidly isolate and determine
the structures and biological activity of natural products, thus
opening up exciting opportunities in the field of new drug
development in the pharmaceutical industry.
Studies in Natural Products Chemistry, Volume 57, covers rapid
developments in spectroscopic techniques and advances in
high-throughput screening techniques that have made it possible to
rapidly isolate and determine the structures and biological
activity of natural products in new drug development. The series
also covers the synthesis of the medicinal properties of natural
products, providing cutting-edge accounts of fascinating
developments in the isolation, structure elucidation, synthesis,
biosynthesis and pharmacology of a diverse array of bioactive
natural products. Specific sections in this release cover
broad-spectrum health protection of extra virgin olive oil
compounds, synthesis of cardiac steroids and their role on heart
failure and cancer, and more.
Studies in Natural Products Chemistry, Volume 56 covers rapid
developments in spectroscopic techniques, also presenting advances
in high-throughput screening techniques, including the new
potential to isolate and determine the structures and biological
activity of natural products and their applications in the field of
new drug development. This ongoing series covers the synthesis,
testing and recording of the medicinal properties of natural
products, providing cutting-edge accounts of fascinating
developments in the isolation, structure elucidation, synthesis,
biosynthesis and pharmacology of a diverse array of bioactive
natural products.
Contents: 1. Inverse Detection Applied to the ^T1>H and 13C Assignment and to the Regiochemical Characterization of ß-substituted Alpha, Alpha Coupled Oligo- and Polythiophenes L. Schenetti and A. Mucci 2. ^T17O NMR of Enol Ethers >^TM.A.P. Martins, G.M. Sigueira, A.F.C. Flores, H.G. Bonacorso, R.A. Freitag and N. Zanatia> 3. Monitoring Interaction of Heterocyclic Drugs with Biological Systems: Combined Approach by Magnetic Relaxation, NOE, and Other Spectroscopic Modalities V.E. Yushmanov 4. Solvent/Water Suppression in NMR W.S. Price 5. Mass Spectrometry in Protein Study Mitsuo Takayama and Akira Tsugita 6. Some Aspects of Mass Spectrometry of Natural ProductsD.A. Ponomarev, V.V. Takhistov and P. Vainiotalo 7. Luminiscence Techniques in Pharmaceutical Analysis. Recent Advances in Experiemental Methods and Chemometric Applications Garciela M. Escandar and Alejandro C. Olivieri 8. Asphaltenes: The "Dark Side" of Petroleum M. Nali
The goal of an activity-directed isolation process is to isolate
bioactive compounds which may provide structural leads of
therapeutic importance. Whereas the traditional process of drug
development is long and expensive, simple and rapid bioassays can
serve as the starting point for drug discovery. This book presents
a range of "bench top" bioassay techniques useful for natural
product and pharmaceutical chemists involved in drug discovery and
pharmacognosy. The contents detail a number of enzyme-based assays,
cell-based functional bioassays and receptor radioligand binding
assays along with detailed descriptions of each type. The majority
of these bioassays are presented in a step-by-step format, so they
could even be implemented by technical personnel with little
background in microbiology, biochemistry or pharmacology.
Studies in Natural Products Chemistry, Volume 73 covers the
synthesis, testing and recording of medicinal properties of natural
products, providing cutting-edge accounts of fascinating
developments in the isolation, structure elucidation, synthesis,
biosynthesis and pharmacology of a diverse array of bioactive
natural products. Natural products in the plant and animal kingdom
offer a huge diversity of chemical structures that are the result
of biosynthetic processes that have been modulated over millennia
through genetic effects. With rapid developments in spectroscopic
techniques and accompanying advances in high-throughput screening
techniques, it has become possible to isolate and determine the
structures and biological activity of natural products. Hence,
these new discoveries have created new avenues and applications for
their use.
Studies in Natural Products Chemistry, Volume 71 covers the
synthesis, testing and recording of the medicinal properties of
natural products, providing cutting-edge accounts of the
fascinating developments in the isolation, structure elucidation,
synthesis, biosynthesis and pharmacology of a diverse array of
bioactive natural products. With the rapid developments in
spectroscopic techniques and accompanying advances in
high-throughput screening techniques, it has become possible to
isolate and then determine the structures and biological activity
of natural products rapidly, thus opening up exciting opportunities
in the field of new drug development to the pharmaceutical
industry. Natural products in the plant and animal kingdom offer a
huge diversity of chemical structures that are the result of
biosynthetic processes that have been modulated over the millennia
through genetic effects, hence users will find the detailed
information in this book to be a great resource on the topics
covered.
Studies in Natural Products Chemistry, Volume 70 covers the
synthesis or testing and recording of the medicinal properties of
natural products, providing cutting-edge accounts of fascinating
developments in the isolation, structure elucidation, synthesis,
biosynthesis and pharmacology of a diverse array of bioactive
natural products. With the rapid developments in spectroscopic
techniques and accompanying advances in high-throughput screening
techniques, this book presents exciting opportunities in the field
of new drug development to the pharmaceutical industry. Natural
products in the plant and animal kingdom offer a huge diversity of
chemical structures that are the result of biosynthetic processes
that have been modulated over the millennia through genetic
effects.
Studies in Natural Products Chemistry, Volume 69 covers the
synthesis, testing and recording of the medicinal properties of
natural products, providing cutting-edge accounts of fascinating
developments in the isolation, structure elucidation, synthesis,
biosynthesis and pharmacology of a diverse array of bioactive
natural products. Natural products in the plant and animal kingdom
offer a huge diversity of chemical structures that are the result
of biosynthetic processes. With rapid developments in spectroscopic
techniques and accompanying advances in high-throughput screening
techniques, it has become possible to rapidly isolate and determine
the structures and biological activity of natural products, thus
opening up opportunities in drug development.
Studies in Natural Products Chemistry, Volume 66 covers the
synthesis, testing, and recording of the medicinal properties of
natural products, providing cutting edge accounts of the
fascinating developments in the isolation, structure elucidation,
synthesis, biosynthesis, and pharmacology of a diverse array of
bioactive natural products. Natural products in the plant and
animal kingdom offer a huge diversity of chemical structures that
are the result of biosynthetic processes that have been modulated
over the millennia through genetic effects. With rapid developments
in spectroscopic techniques and accompanying advances in
high-throughput screening techniques, it has become possible to
isolate and determine the structures and biological activity of
natural products rapidly, thus opening up exciting opportunities in
new drug development for the pharmaceutical industry.
Studies in Natural Products Chemistry, Volume 79 covers the
synthesis, testing and recording of the medicinal properties of
natural products, providing cutting-edge accounts of fascinating
developments in the isolation, structure elucidation, synthesis,
biosynthesis and pharmacology of a diverse array of bioactive
natural products. Natural products in the plant and animal kingdom
offer a huge diversity of chemical structures that are the result
of biosynthetic processes that have been modulated over the
millennia through genetic effects. With the rapid developments in
spectroscopic techniques and accompanying advances in
high-throughput screening techniques, it's possible to isolate and
rapidly determine the structures and biological activity of natural
products.
Studies in Natural Products Chemistry, Volume 53, covers the
synthesis, testing, and recording of the medicinal properties of
natural products, providing cutting-edge accounts of the
fascinating developments in the isolation, structure elucidation,
synthesis, biosynthesis, and pharmacology of a diverse array of
bioactive natural products. Natural products in the plant and
animal kingdom offer a huge diversity of chemical structures that
are the result of biosynthetic processes that have been modulated
over the millennia through genetic effects. With the rapid
developments in spectroscopic techniques and accompanying advances
in high-throughput screening techniques, it has become possible to
isolate and then determine the structures and biological activity
of natural products rapidly, thus opening up exciting opportunities
in the field of new drug development to the pharmaceutical industry
that are discussed and highlighted in this series.
Studies in Natural Products Chemistry covers the synthesis,
testing, and recording of the medicinal properties of natural
products, providing cutting-edge accounts of the fascinating
developments in the isolation, structure elucidation, synthesis,
biosynthesis, and pharmacology of a diverse array of bioactive
natural products. Natural products in the plant and animal kingdom
offer a huge diversity of chemical structures that are the result
of biosynthetic processes that have been modulated over the
millennia through genetic effects. With the rapid developments in
spectroscopic techniques and accompanying advances in
high-throughput screening techniques, it has become possible to
isolate and then rapidly determine the structures and biological
activity of natural products, thus opening up exciting
opportunities in the field of new drug development in the
pharmaceutical industry.
Natural products in the plant and animal kingdom offer a huge
diversity of chemical structures that are the result of
biosynthetic processes that have been modulated over the millennia
through genetic effects. With the rapid developments in
spectroscopic techniques and accompanying advances in
high-throughput screening techniques, it has become possible to
isolate and then determine the structures and biological activity
of natural products rapidly, thus opening up exciting opportunities
in the field of new drug development to the pharmaceutical
industry. This series covers the synthesis or testing and recording
of the medicinal properties of natural products, providing cutting
edge accounts of the fascinating developments in the isolation,
structure elucidation, synthesis, biosynthesis and pharmacology of
a diverse array of bioactive natural products.
This book is a pioneering regional work and provides a balanced
approach of theory and practice in disaster risk reduction (DRR) in
Pakistan. The book analytically discusses the status of DRR and
draws examples and lessons from national and community-level
programs and projects and events in the country. The book covers
different types of disasters facing Pakistan, including
geo-physical and hydro-meteorological hazards. This work
incorporates and draws some of the key lessons learned from the
pre-disaster and disaster phases to the post-disaster phase,
providing an effective framework in the form of those lessons. The
rich content is based on a selection of available documents, a
consultative workshop with academicians from different universities
undertaking DRR higher education programs, and the editors' own
knowledge and experience in the field. Special emphasis is given to
analyzing field experiences from academic perspectives, and
pinpointing key issues and the policy relevance of DRR. Disaster
Risk Reduction Approaches in Pakistan is organized into three
sections with a total of 20 chapters. Section one provides the
outline and basics of DRR strategies applied at the national level
with supporting examples from a global review. Section two
specifically highlights the wide ranges of hazards experienced in
Pakistan and presents examples, policy options, institutional
set-ups, risk reduction strategies, and key lessons learned. The
third section of the book is given to approaches and issues of DRR
practices with examples of disaster responses.
Recent advancements in the field of asymmetric synthesis have been
triggered by the challenges this field has offered to synthetic
organic chemists, and the importance of preparing optically active
compounds of medical value. Newly developed asymmetric organic
reactions combined with improvements and novel applications of
previously known reactions have created the need for this current
volume. Presenting findings reported in 1991, this book covers
asymmetric oxidations, reductions, carbon-- carbon bond formations,
carbon--heteroatom bond formations, enzymatic hydrolysis,
resolution and transesterification and miscellaneous asymmetric
reactions. This book will serve as a useful reference for all
researchers, scientists and students working in the field of
synthetic organic chemistry.
13C-NMR spectroscopy plays an important role in the elucidation of
organic compound structures. Chemists researching new compounds
will find this volume, which covers the 13C-NMR data of diterpenes,
a valuable reference source.
This monumental tome by Prof. Atta-ur-Rahman and Dr. Zahir Shah
pres- ents a broad overall perspective of stereo selectivity in the
synthesis of or- ganic molecules. Thus it treats a problem that is
of fundamental importance and will be even more important in the
future as the drug industry is required to supply 1000/0 optically
pure compounds. After an exposition of general principles, the
following subjects are treated: Catalytic Reductions, Heterogeneous
Catalytic Hydrogenations, Stereoselective Non-Catalytic Reductions,
Stereos elective Carbon-Carbon Bond Forming Reactions, Asymmetric
Oxidations, Asymmetric Carbon- Heteroatom Bond Formations, Enzyme
Catalyzed Reactions, Stereo- selective Free Radical Reactions, and
finally Miscellaneous Stereoselective Reactions. For each subject,
a wealth of examples are given. The highly selective reactions are
mentioned along with reactions that are not. This is helpful as it
will teach the practical chemist what to avoid. Much progress has
been made in the last two decades in the design of new, very
stereoselective reactions which can be applied in industry. For
example, and in alphabetical order, we can mention (among other
peers): H.C. Brown (hydroboration), D.C. Evans (carbon-carbon bond
forma- tion), R. Noyori (BINAP reagents for hydrogenation), and
K.B. Sharpless (epoxidation and dihydroxylation of double bonds).
Thus the field has completely changed since the 1950s, when
optically pure compounds were always obtained by difficult
resolutions of racemates and not by stereoselec- tive reactions.
Natural product chemistry has undergone an explosive growth during
the latter half of the current century. This has been brought about
by a number of factors. One of these has been the growing number of
sub stances from natural sources which display interesting
pharmacological activities. These include antibiotics, anti-tumor
agents, immunostimu lants, drugs affecting the cardiovascular and
central nervous systems, analgesics etc. Another factor has been
the improvements made in the technology of isolation processes
which includes the development of such techniques as high pressure
liquid chromatography which has al lowed the rapid isolation of
substances which were previously diffi cult to obtain by classical
procedures. The most important factor has been the development of
new spectrosopic techniques which have opened up whole new vistas
in this exciting field. Prominent in these advan ces has been the
advent of powerful superconducting magnets with very stable
magnetic fields, and pulse NMR in which the duration, direction and
phases of pulses can be accurately controlled by means of mini
computers. These have heralded the advent of two-dimensional NMR
spec troscopy which has now come to be routinely employed in
unravelling complex structures. No less important, though somewhat
less dramatic, have been the advances made in the field of mass
spectroscopy where new ionization techniques such as positive and
negative fast atom bom bardment, field desorption, chemical
ionization etc. have allowed the mass spectra of larger
non-volatile substances to be recorded. The field of organic
synthesis has seen equally rapid advances."
The First International Symposium and Pakistan-U.S. Binational
Workshop on Natural Product Chemistry represents the first
international conference ever to be organised in Pakistan on
chemistry. For many years I had aspired to organise such a con-
ference, and finally when it materialised in February 1984, it
brought together the very best in the field. The result was as
expected - a most stimulating series of lectures and discussions,
all of which were recorded on videotape for circulation to uni-
versities and research organisations in Pakistan. The fields
covered during the Symposium include such diverse areas as plant
chemistry, marine natural products, insect hormones, glycopro-
teins and peptides, synthetic methodology and spectroscopy. I am
confident that the papers published here would prove invalu- able
to the natural product chemists and biochemists working in the
fascinating area of natural products. I wish to record here my
indebtedness to Professor Philip W. Le Quesne and Professor
Wolfgang Voelter for their untiring efforts in organising the
visits of the U.S. and German scien- tists. I am grateful to the
National Science Foundation (USA), Deutsche Forschungsgemeinschaft,
U.N.E.S.C.O., Hamdard National Foundation, Pakistan Science
Foundation, University Grants Commission, Ministry of Science and
Technology, British Council, B.A.S.F. and E. Merck for providing
financial support for the conference. But above all, the conference
owes its success to the students and staff of the Institute who
worked so very hard.
Nuclear magnetic resonance spectroscopy is presently going through
an explosive phase of development. This has been brought about
largely on account of the advent of Fourier transform NMR
spectrometers linked to powerful microcomputers which have opened
up a whole new world for structural chemists and biochemists. This
is exemplified by a host of publications, especially on new pulse
sequences, which continue to provide new exciting modifications for
recording two-dimensional NMR. Moreover, NMR is no longer confined
to structural chemists but has moved firmly into the area of
medicine as a powerful nondestructive body scanning technique. With
this background, I felt that there was need for a text which would
provide a fairly comprehensive account of the important features of
1 H- and 13C-NMR spectroscopy in one book, as well as make
available an up-to-date account of recent developments of new pulse
sequences, with particular reference to 2D-NMR spectroscopy. Since
this book is written for students of chemistry and biochemistry as
well as for biology students who have chemistry as a subsidiary, it
was decided to avoid a complex mathematical treatment and to
present, as far as possible without oversimplification, a
qualitative account of 1 H- and 13C-NMR spectroscopy as it is
today. I hope that the book satisfactorily meets these objectives.
Studies in Natural Products Chemistry, Volume 78 covers the
synthesis or testing and recording of the medicinal properties of
natural products, providing cutting-edge accounts of the
fascinating developments in the isolation, structure elucidation,
synthesis, biosynthesis and pharmacology of a diverse array of
bioactive natural products. Natural products in the plant and
animal kingdom offer a huge diversity of chemical structures that
are the result of biosynthetic processes that have been modulated
over the millennia through genetic effects. With rapid developments
in spectroscopic techniques and accompanying advances in
high-throughput screening techniques, it has become possible to
isolate and then determine the structures and biological activity
of natural products rapidly, thus opening up exciting opportunities
in the field of new drug development to the pharmaceutical
industry.
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